Date of Award

Fall 2007

Document Type

Thesis

Degree Name

Master of Science in Computational Biology - (M.S.)

Department

Computer Science

First Advisor

Jason T. L. Wang

Second Advisor

Andrew Sohn

Third Advisor

Dimitri Theodoratos

Abstract

The goal of this project is to identify untranslated regions (UTRs) and UTR-indicating patterns in the genome of T. brucei. T. brucei is an interesting organism, and as the cause of African sleeping sickness -- which infects 300,000-500,000 people and a significant number of cattle annually -- is currently the subject of considerable research. Using existing algorithms, several patterns have been found that may lead to more complete UTR annotations in the T. brucei genome. The most encouraging sequence is the 11-base sequence GAGGGIICG]TGGGG, which appears in five hypothetical genes near the tail. Discovery of several such sequences could guide laboratory experimentation toward more useful results and a better allocation of time and resources.

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