Document Type
Thesis
Date of Award
8-31-1988
Degree Name
Master of Science in Biomedical Engineering - (M.S.)
Department
Biomedical Engineering Committee
First Advisor
Samir S. Sofer
Second Advisor
David S. Kristol
Third Advisor
Arthur B. Ritter
Abstract
A simple numerical simulation of an AIDS patient detoxification by an extracorporeal device for the removal of virus has been designed. The mathematical model accounts for healthy white cells (W) attacking and destroying the virus (V), while at the same time the virus attacks and infects certain white cells. The infected white cells (Wi) serve as a site for viral growth, and finally the cell is lysed, releasing a large number of viruses in the blood stream. This model can be used to predict concentrations over a given period for the patient.
The device incorporates an antitwister mechanism allowing for continuous feed and collection lines to be attached directly to the rotating centrifuge head, eliminating the necessity to use a rotating seal. Experimental studies have been performed using a radial-flow centrifuge head by varying parameters such as hematocrit of feed blood, speed of centrifuge and withdrawal rate of sample. Initial studies indicate that the device is capable of separating plasma from blood cellular components on a continuous basis. Since virally infected white cells have different surface properties and densities, it is possible that under special conditions, they may be separated from other cellular components, and may provide AIDS patients with relief in the early stages of the disease and extended survival.
Recommended Citation
Kapadvanjwala, Mansoor Yusuf, "Simulation of AIDS patient detoxification by an extracorporeal device and related experimental studies" (1988). Theses. 3111.
https://digitalcommons.njit.edu/theses/3111
