Document Type
Thesis
Date of Award
12-31-1988
Degree Name
Master of Science in Biomedical Engineering - (M.S.)
Department
Biomedical Engineering Committee
First Advisor
David S. Kristol
Second Advisor
Stephen D. Siegel
Third Advisor
Stanley S. Reisman
Abstract
The purpose of this investigation is to develop methodology for the standard measurement and physiological interpretation of lung resistance and compliance using non-invasive forced oscillations techniques and validating these results with standardized esophageal balloon techniques. Application of the forced oscillation technique with an esophageal balloon in place permits partitioning of the respiratory system into the pulmonary system which is of primary interest and the less clinically important chestwall system. Diseased lung states are induced in normal subjects by inhalation of a bronchoconstrictor. The total respiratory (pulmonary plus chest wall) and pulmonary impedances are interpreted using both a linear three element model and a nonlinear five element model of total respiratory system.
The forced oscillation technique yields parameters that are physiologically relevant and agree with those obtained from standard invasive tests. The five element model interpretation of the pulmonary system has indicated that the forced oscillation test is sensitive to changes in pulmonary mechanics as indicated by the standard invasive tests. Finally, the forced oscillation test applied without the esophageal balloon has been shown to be more sensitive than currently used pulmonary function tests, and sufficient to characterize changes in lung mechanics. It is anticipated that future refinement and application of these techniques will lead to further clinical application in the detection and treatment of pulmonary disease.
Recommended Citation
Fisler, Richard Thomas, "Respiratory impedances computed from the forced oscillation technique using an esophageal balloon" (1988). Theses. 3069.
https://digitalcommons.njit.edu/theses/3069
