Document Type
Thesis
Date of Award
5-31-1988
Degree Name
Master of Science in Electrical Engineering - (M.S.)
Department
Electrical Engineering
First Advisor
Peter Engler
Second Advisor
Stanley S. Reisman
Abstract
In a model of rats resuscitated from hemorrhagic shock,where 11 of 12 animals were alive up to 4 hours after shock, there was an average drop of 10°C in core body temperature. Survival and morbidity was much impaired when the shocked animals were externally heated with an infrared lamp to maintain a core body temperature of 35°C. Since the increased intrashock mortality is possibly due to the circulatory changes induced by peripheral heating, an attempt was made to determine the effects of heating the animal at its core. Twelve rats were shocked in the same fashion, however the body core temperature was maintained between 34°C and 36°C using 2450 MHz microwave radiation at power density of approximately 60 mw/cm2. This wavelength of electromagnetic energy will be converted to thermal energy within depth of approximately 2 cm in biological tissues.
Initial blood pressure (BP), final BP, and total blood shed were the same for all surviving animals at the end of shock in all groups. Survival was significantly better in the hypothermic animals (p< .015), and, based on the limited data base we have, there appears to be no significant difference in survival between either of the heated groups. Animals tolerated shock for 5 hours in the hypothermic group and only 2.5 hours in the microwave-heated group and 2.0 hours in the peripheral- heated group (p<.01). It appears that hypothermia increases tolerance to hemorrhagic shock in this model and improves both acute and long term survival. This introduces the question: What is the ideal temperature for maintenance of patients in hemorrhagic shock ?
Recommended Citation
El-Assuooty, Ashraf Sabry, "Effects of peripheral and microwave-core heating on survival in hemorrhagic shock in rats" (1988). Theses. 3065.
https://digitalcommons.njit.edu/theses/3065
