Date of Award

Fall 2008

Document Type

Thesis

Degree Name

Master of Science in Pharmaceutical Engineering - (M.S.)

Department

Chemical, Biological and Pharmaceutical Engineering

First Advisor

Rajesh N. Dave

Second Advisor

Piero M. Armenante

Third Advisor

S. Mitra

Abstract

Application of nanotechnology in pharmaceutical research has opened new frontiers for drug development and its efficient delivery. In recent years, the focus of the research has been on the engineering of nano/micro-particulate structures for efficient and targeted delivery of drugs for selective and enhanced absorption. This work throws light on the preparation of biodegradable and non-toxic nanoparticulate systems for targeted drug delivery. The drug vehicles were made by two different processes namely electrostatic interactions and desolvation process. The drug carriers made by these processes were found to be in the size range of 150-200nm which is necessary for cellular uptake of the drug carriers. The albumin nanocarriers were modified by antibody and showed binding to the Ramos lymphoma cells in-vitro.

Formation of nano-sized Active Pharmaceutical Ingredient (API) particles is another application of nanotechnology, where small size leads to improved solubility. Hence the API size reduction by milling was carried out to increase the bioavailability of the APIs after their incorporation in different dosage forms. The stable aqueous suspensions of the API were obtained using polymers and surfactants which could be mixed with excipients and formulated into thin film strips.

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