Document Type


Date of Award

Winter 1994

Degree Name

Master of Science in Biomedical Engineering - (M.S.)


Biomedical Engineering Committee

First Advisor

Rose Ann Dios

Second Advisor

David S. Kristol

Third Advisor

Peter Engler


This research explores the impact of a variety patient, disease and lesion parameters upon the probability of post surgery recurrence of squamous cell carcinoma and the involvement of histologic nodes. It was found that parameters such as number of nodes, Lymph Vascular Space Invasion (LVS), figo stage, growth rate and host response as well as tumor thickness, depth of invasion and lesion size are good predictors. Other parameters such as cell type and condylomas were found to correlate minimally with recurrence and histologic nodes. Surgical parameters such as surgical margin and distance surgical margin were found to have poor correlation with either recurrence or histologic node involvement.

In addition, a statistical model was developed to predict the likelihood of disease recurrence and histological node involvement based on the parameters found significant in this study.