Date of Award

Spring 1983

Document Type

Thesis

Degree Name

Master of Science in Chemical Engineering - (M.S.)

Department

Chemical Engineering and Chemistry

First Advisor

Ching-Rong Huang

Second Advisor

David S. Kristol

Third Advisor

Chen-Chong Lin

Abstract

A mathematical model of the blood-glucose regulatory system has been developed. This model describes an oral glucose tolerance test adequately and simulates the behavior of the real physiological system using computer techniques.

Regression of the rate constants involved have been effected by conforming the theoretical functions to the data from glucose tolerance test in nonobese normal subjects, obese normal subjects, nonobese mild diabetics, obese mild diabetics, nonobese moderate diabetics and obese moderate diabetics measured by continuous sampling after oral ingestion. Most of the data were conformed within the limits of experimental error. The result of optimal parameters lead to a criterion for separating normal subjects from mild diabetics and moderate diabetics.

The significance of the model conformation is discussed in view of the goals of modeling and the extension of knowledge of blood-glucose mechanism in the human body.

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