The ovarian cancer oncobiome

Document Type

Article

Publication Date

5-30-2017

Abstract

Humans and other mammals are colonized by microbial agents across the kingdom which can represent a unique microbiome pattern. Dysbiosis of the microbiome has been associated with pathology including cancer. We have identified a microbiome signature unique to ovarian cancers, one of the most lethal malignancies of the female reproductive system, primarily because of its asymptomatic nature during the early stages in development. We screened ovarian cancer samples along with matched, and non-matched control samples using our pan-pathogen array (PathoChip), combined with capture-next generation sequencing. The results show a distinct group of viral, bacterial, fungal and parasitic signatures of high significance in ovarian cases. Further analysis shows specific viral integration sites within the host genome of tumor samples, which may contribute to the carcinogenic process. The ovarian cancer microbiome signature provides insights for the development of targeted therapeutics against ovarian cancers.

Identifier

85029940140 (Scopus)

Publication Title

Oncotarget

External Full Text Location

https://doi.org/10.18632/oncotarget.16717

e-ISSN

19492553

PubMed ID

28410234

First Page

36225

Last Page

36245

Issue

22

Volume

8

Grant

P30CA016520

Fund Ref

National Cancer Institute

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