Common variants in MMP20 at 11q22.2 predispose to 11q deletion and neuroblastoma risk
Document Type
Article
Publication Date
12-1-2017
Abstract
MYCN amplification and 11q deletion are two inversely correlated prognostic factors of poor outcome in neuroblastoma. Here we identify common variants at 11q22.2 within MMP20 that associate with neuroblastoma cases harboring 11q deletion (rs10895322), using GWAS in 113 European-American cases and 5109 ancestry-matched controls. The association is replicated in 44 independent cases and 1902 controls. Our study yields novel insights into the genetic underpinnings of neuroblastoma, demonstrating that the inherited common variants reported contribute to the origin of intra-tumor genetic heterogeneity in neuroblastoma.
Identifier
85029573901 (Scopus)
Publication Title
Nature Communications
External Full Text Location
https://doi.org/10.1038/s41467-017-00408-8
e-ISSN
20411723
PubMed ID
28924153
Issue
1
Volume
8
Grant
CA98543
Fund Ref
National Institutes of Health
Recommended Citation
Chang, Xiao; Zhao, Yan; Hou, Cuiping; Glessner, Joseph; McDaniel, Lee; Diamond, Maura A.; Thomas, Kelly; Li, Jin; Wei, Zhi; Liu, Yichuan; Guo, Yiran; Mentch, Frank D.; Qiu, Haijun; Kim, Cecilia; Evans, Perry; Vaksman, Zalman; Diskin, Sharon J.; Attiyeh, Edward F.; and Sleiman, Patrick, "Common variants in MMP20 at 11q22.2 predispose to 11q deletion and neuroblastoma risk" (2017). Faculty Publications. 9163.
https://digitalcommons.njit.edu/fac_pubs/9163
