Injectable self-assembling peptide hydrogels for tissue writing and embryonic stem cell culture

Document Type

Article

Publication Date

4-1-2018

Abstract

The fabrication of extracellular matrix-mimic hydrogels that can nurture and direct differentiation of embryonic stem cells is an important target for pattern-printed tissue replacement. Another desirable feature for such materials is their ability to be injected and recover their rheological features post-injection, allowing for facile non-invasive implantation. In this report, we demonstrate the ability of a self-assembling peptide hydrogel to support the culture of embryonic stem cells with the potential to direct differentiation. We also show that we can write a functional tissue replacement with a predetermined pattern using our formulation. Our results may lead to in vivo replacement of diseased tissue with a spatially resolved pattern of a regenerative hydrogel.

Identifier

85047599711 (Scopus)

Publication Title

Journal of Biomedical Nanotechnology

External Full Text Location

https://doi.org/10.1166/jbn.2018.2583

e-ISSN

15507041

ISSN

15507033

PubMed ID

31352954

First Page

802

Last Page

807

Issue

4

Volume

14

This document is currently not available here.

Share

COinS