Lysosome-targeting NIR ratiometric luminecent upcoversion nanoprobe toward arginine

Document Type

Article

Publication Date

2-1-2019

Abstract

Near-infrared (NIR) fluorescent sensors have been actively pursued due to organisms exhibiting little autofluorescence in near-infrared regions. Capable of emitting luminesence under 980 nm excitation, upconversion nanoparticles have shown promise as optical agents for in vivo bioimaging. Based on luminescence resonance energy transfer (LRET), a NIR luminescent Arg-nanoprobe was developed by the decoration of upconversion nanoparticles (UCNPs) (NaYF4:Yb,Er) with organic molecules. The as-developed nanoprobe could quantitatively detect concentrations within the range of 528–1250 μM, and had high sensitiviy (the limit of detection, LOD, being 15.6 μM) and good photostability. Because the probe could target lysosomes, intracellar detection of Arg behavior was demonstrated via upconversion luminescence (UCL) imaging.

Identifier

85054800493 (Scopus)

Publication Title

Sensors and Actuators B Chemical

External Full Text Location

https://doi.org/10.1016/j.snb.2018.10.057

ISSN

09254005

First Page

94

Last Page

101

Volume

280

Grant

21601158

Fund Ref

National Natural Science Foundation of China

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