Effects of tributyltin on placental and abnormalities in offspring
Document Type
Article
Publication Date
1-1-2024
Abstract
Tributyltin (TBT) is an organotin compound and a common persistent environmental pollutant with endocrine-disrupting chemical (EDC) actions. It can accumulate in the environment at various concentrations throughout the food chain in the ecosystem, posing a risk to human health, especially during critical periods such as gestation and fetal and offspring development. In this review, we report the results of studies describing the consequences of TBT exposure on placental and reproductive parameters in offspring of both sexes. Results from in vivo and in vitro studies clearly indicate that TBT causes adverse effects on placental development and reproductive parameters in offspring. However, substantial knowledge gaps remain in the literature, requiring further research to better understand the mechanisms behind TBT effects on placental and reproductive disruption in offspring.
Identifier
85217271087 (Scopus)
Publication Title
Archives of Endocrinology and Metabolism
External Full Text Location
https://doi.org/10.20945/2359-4292-2024-0186
e-ISSN
23594292
ISSN
23593997
PubMed ID
39876959
Issue
Special-Issue1
Volume
68
Grant
572/2018
Fund Ref
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Recommended Citation
da Costa, Charles S.; Alahmadi, Hanin; Warner, Genoa R.; Nunes, Maria Tereza; Dias, Glaecir Roseni Mundstock; Miranda-Alves, Leandro; and Graceli, Jones B., "Effects of tributyltin on placental and abnormalities in offspring" (2024). Faculty Publications. 731.
https://digitalcommons.njit.edu/fac_pubs/731
