Self-Assembling Peptides with Insulin-Like Growth Factor Mimicry
Document Type
Article
Publication Date
1-10-2024
Abstract
Growth factor (GF) mimicry involves recapitulating the signaling of larger molecules or cells. Although GF mimicry holds considerable promise in tissue engineering and drug design applications, difficulties in targeting the signaling molecule to the site of delivery and dissociation of mimicking peptides from their target receptors continue to limit its clinical application. To address these challenges, we utilized a self-assembling peptide (SAP) platform to generate synthetic insulin-like growth factor (IGF)-signaling, self-assembling GFs. Our peptide hydrogels are biocompatible and bind target IGF receptors in a dose-dependent fashion, activate proangiogenic signaling, and facilitate formation of angiogenic microtubules in vitro. Furthermore, infiltrated hydrogels are stable for weeks to months. We conclude that the enhanced targeting and long-term stability of our SAP/GF mimicry implants may improve the efficacy and safety of future GF mimic therapeutics.
Identifier
85181803030 (Scopus)
Publication Title
ACS Applied Materials and Interfaces
External Full Text Location
https://doi.org/10.1021/acsami.3c15660
e-ISSN
19448252
ISSN
19448244
PubMed ID
38145951
First Page
364
Last Page
375
Issue
1
Volume
16
Grant
R15 EY029504
Fund Ref
National Institutes of Health
Recommended Citation
Roy, Abhishek; Dodd-O, Joseph B.; Robang, Alicia S.; He, Dongjing; West, Owen; Siddiqui, Zain; Aguas, Erika Davidoff; Goldberg, Hannah; Griffith, Alexandra; Heffernan, Corey; Hu, Yuhang; Paravastu, Anant K.; and Kumar, Vivek A., "Self-Assembling Peptides with Insulin-Like Growth Factor Mimicry" (2024). Faculty Publications. 683.
https://digitalcommons.njit.edu/fac_pubs/683
