Peptide Self-Assembly into Amyloid Fibrils: Unbiased All-Atom Simulations

Document Type

Article

Publication Date

4-11-2024

Abstract

Protein self-assembly plays an important role in biological systems, accounting for the formation of mesoscopic structures that can be highly symmetric as in the capsid of viruses or disordered as in molecular condensates or exhibit a one-dimensional fibrillar morphology as in amyloid fibrils. Deposits of the latter in tissues of individuals with degenerative diseases like Alzheimer’s and Parkinson’s has motivated extensive efforts to understand the sequence of molecular events accounting for their formation. These studies aim to identify on-pathway intermediates that may be the targets for therapeutic intervention. This detailed knowledge of fibril formation remains obscure, in part due to challenges with experimental analyses of these processes. However, important progress is being achieved for short amyloid peptides due to advances in our ability to perform completely unbiased all-atom simulations of the self-assembly process. This perspective discusses recent developments, their implications, and the hurdles that still need to be overcome to further advance the field.

Identifier

85187109907 (Scopus)

Publication Title

Journal of Physical Chemistry B

External Full Text Location

https://doi.org/10.1021/acs.jpcb.3c07861

e-ISSN

15205207

ISSN

15206106

PubMed ID

38447080

First Page

3320

Last Page

3328

Issue

14

Volume

128

Grant

CHE-2304853

Fund Ref

National Science Foundation

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