A review of recent advances in the use of complex metal nanostructures for biomedical applications from diagnosis to treatment

Document Type

Article

Publication Date

5-1-2024

Abstract

Complex metal nanostructures represent an exceptional category of materials characterized by distinct morphologies and physicochemical properties. Nanostructures with shape anisotropies, such as nanorods, nanostars, nanocages, and nanoprisms, are particularly appealing due to their tunable surface plasmon resonances, controllable surface chemistries, and effective targeting capabilities. These complex nanostructures can absorb light in the near-infrared, enabling noteworthy applications in nanomedicine, molecular imaging, and biology. The engineering of targeting abilities through surface modifications involving ligands, antibodies, peptides, and other agents potentiates their effects. Recent years have witnessed the development of innovative structures with diverse compositions, expanding their applications in biomedicine. These applications encompass targeted imaging, surface-enhanced Raman spectroscopy, near-infrared II imaging, catalytic therapy, photothermal therapy, and cancer treatment. This review seeks to provide the nanomedicine community with a thorough and informative overview of the evolving landscape of complex metal nanoparticle research, with a specific emphasis on their roles in imaging, cancer therapy, infectious diseases, and biofilm treatment. This article is categorized under: Diagnostic Tools > In Vivo Nanodiagnostics and Imaging Therapeutic Approaches and Drug Discovery > Nanomedicine for Infectious Disease Diagnostic Tools > Diagnostic Nanodevices.

Identifier

85192175345 (Scopus)

Publication Title

Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology

External Full Text Location

https://doi.org/10.1002/wnan.1959

e-ISSN

19390041

ISSN

19395116

PubMed ID

38711134

Issue

3

Volume

16

Grant

R00‐EB028838

Fund Ref

National Institutes of Health

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