ESSENCE - Cost-effective, universal, modular, electrochemical sensor for rapid, sensitive, and selective detection of DNA, proteins in a low resource setting

Document Type

Conference Proceeding

Publication Date

1-1-2021

Abstract

The sensor platform, ESSENCE, uses a Shear-Enhanced, flow-through non-planar 3D Nanoporous Electrode to overcomes current electrochemical sensors' selectivity and sensitivity limitations. The porous electrode architecture enhances shear forces (high selectivity), increased convective fluxes that disrupt diffusive processes (rapid measurements) like electric double layer, enhanced electric field penetration with the removal of parasitic noises (high sensitivity). The unique chip architecture allows us to assemble the chip at point-of-use (modular, solving cold chain issues) and target different classes of biomolecules (universal platform). ESSENCE detects DNA and proteins with fM and pg/L sensitivity, respectively, against other background molecules and in undiluted urine.

Identifier

85136975801 (Scopus)

ISBN

[9781733419031]

Publication Title

Microtas 2021 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences

First Page

1505

Last Page

1506

Grant

1751759

Fund Ref

National Science Foundation

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