The Effect of Physical Cues of Biomaterial Scaffolds on Stem Cell Behavior
Document Type
Article
Publication Date
2-1-2021
Abstract
Stem cells have been sought as a promising cell source in the tissue engineering field due to their proliferative capacity as well as differentiation potential. Biomaterials have been utilized to facilitate the delivery of stem cells in order to improve their engraftment and long-term viability upon implantation. Biomaterials also have been developed as scaffolds to promote stem cell induced tissue regeneration. This review focuses on the latter where the biomaterial scaffold is designed to provide physical cues to stem cells in order to promote their behavior for tissue formation. Recent work that explores the effect of scaffold physical properties, topography, mechanical properties and electrical properties, is discussed. Although still being elucidated, the biological mechanisms, including cell shape, focal adhesion distribution, and nuclear shape, are presented. This review also discusses emerging areas and challenges in clinical translation.
Identifier
85097008030 (Scopus)
Publication Title
Advanced Healthcare Materials
External Full Text Location
https://doi.org/10.1002/adhm.202001244
e-ISSN
21922659
ISSN
21922640
PubMed ID
33274860
Issue
3
Volume
10
Grant
CMMI‐ 1548571
Fund Ref
National Science Foundation
Recommended Citation
Wang, Shuo; Hashemi, Sharareh; Stratton, Scott; and Arinzeh, Treena Livingston, "The Effect of Physical Cues of Biomaterial Scaffolds on Stem Cell Behavior" (2021). Faculty Publications. 4341.
https://digitalcommons.njit.edu/fac_pubs/4341