Divergent Alterations of Structural–Functional Connectivity Couplings in First-episode and Chronic Schizophrenia Patients

Document Type

Article

Publication Date

4-15-2021

Abstract

Emerging evidence suggests that the coupling relating the structural connectivity (SC) of the brain to its functional connectivity (FC) exhibits remarkable changes during development, normal aging, and diseases. Although altered structural–functional connectivity couplings (SC–FC couplings) have been previously reported in schizophrenia patients, the alterations in SC–FC couplings of different illness stages of schizophrenia (SZ) remain largely unknown. In this study, we collected structural and resting-state functional MRI data from 73 normal controls (NCs), 61 first-episode (FeSZ) and 78 chronic (CSZ) schizophrenia patients. Positive and negative syndrome scale (PANSS) scores were assessed for all patients. Structural and functional brain networks were constructed using gray matter volume (GMV) and resting-state magnetic resonance imaging (rs-fMRI) time series measurements. At the connectivity level, the CSZ patients showed significantly increased SC–FC coupling strength compared with the FeSZ patients. At the node strength level, significant decreased SC–FC coupling strength was observed in the FeSZ patients compared to that of the NCs, and the coupling strength was positively correlated with negative PANSS scores. These results demonstrated divergent alterations of SC–FC couplings in FeSZ and CSZ patients. Our findings provide new insight into the neuropathological mechanisms underlying the developmental course of SZ.

Identifier

85101829030 (Scopus)

Publication Title

Neuroscience

External Full Text Location

https://doi.org/10.1016/j.neuroscience.2021.02.008

e-ISSN

18737544

ISSN

03064522

PubMed ID

33588002

First Page

1

Last Page

12

Volume

460

Grant

31771074

Fund Ref

National Natural Science Foundation of China

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