Recent advances in the stereoselective synthesis of acyclic all-carbon tetrasubstituted alkenes

Document Type

Article

Publication Date

4-30-2021

Abstract

Alkenes bearing four carbon-based groups are ubiquitous motifs in chemical sciences due to their various applications from medicinal to materials chemistry, and as chemical platforms for the synthesis of complex, chiral molecules. As such, tremendous research efforts are currently ongoing in order to develop general procedures for the challenging stereoselective synthesis of all-carbon tetrasubstituted alkenes, especially for acyclic structures. Since classical approaches to carbon-carbon double bonds are not suitable for the high steric demand around tetrasubstituted alkenes, a variety of unique approaches to access these privileged functional groups have been developed in recent years. This review article highlights the most significant developments in the field from 2007 to 2020, with an emphasis on the mechanisms and remaining limitations of these contemporary methods. Specifically, recent advances in internal alkyne carbofunctionalizations, in multicomponent couplings or other cross-couplings from nucleophilic or electrophilic alkenyl partners, and in the development of miscellaneous methods, are discussed. This journal is

Identifier

85104985708 (Scopus)

Publication Title

Chemical Communications

External Full Text Location

https://doi.org/10.1039/d1cc00596k

e-ISSN

1364548X

ISSN

13597345

PubMed ID

33908457

First Page

4071

Last Page

4088

Issue

34

Volume

57

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