Brain gray matter structures associated with trait impulsivity: A systematic review and voxel-based meta-analysis

Document Type

Article

Publication Date

5-1-2021

Abstract

Trait impulsivity is a multifaceted personality characteristic that contributes to maladaptive life outcomes. Although a growing body of neuroimaging studies have investigated the structural correlates of trait impulsivity, the findings remain highly inconsistent and heterogeneous. Herein, we performed a systematic review to depict an integrated delineation of gray matter (GM) substrates of trait impulsivity and a meta-analysis to examine concurrence across previous whole-brain voxel-based morphometry studies. The systematic review summarized the diverse findings in GM morphometry in the past literature, and the quantitative meta-analysis revealed impulsivity-related volumetric GM alterations in prefrontal, temporal, and parietal cortices. In addition, we identified the modulatory effects of age and gender in impulsivity-GM volume associations. The present study advances understanding of brain GM morphometry features underlying trait impulsivity. The findings may have practical implications in the clinical diagnosis of and intervention for impulsivity-related disorders.

Identifier

85100877557 (Scopus)

Publication Title

Human Brain Mapping

External Full Text Location

https://doi.org/10.1002/hbm.25361

e-ISSN

10970193

ISSN

10659471

PubMed ID

33599347

First Page

2214

Last Page

2235

Issue

7

Volume

42

Grant

31800963

Fund Ref

National Natural Science Foundation of China

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