Neutral rhodol-based dyes expressing localization in mitochondria

Authors

Ilaria Ferraboschi, Università di Parma
Juraj Ovcar, Institut Ruđer Bošković
Kateryna V. Vygranenko, Institute of Organic Chemistry of the Polish Academy of Sciences
Shupei Yu, New Jersey Institute of Technology
Alfonso Minervino, New Jersey Institute of Technology
Antoni Wrzosek, Nencki Institute of Experimental Biology of the Polish Academy of Sciences
Adam Szewczyk, Nencki Institute of Experimental Biology of the Polish Academy of Sciences
Riccardo Rozza, CNR-Istituto Officina dei Materiali
Alessandra Magistrato, CNR-Istituto Officina dei Materiali
Kevin D. Belfield, New Jersey Institute of Technology
Daniel T. Gryko, Institute of Organic Chemistry of the Polish Academy of Sciences
Luca Grisanti, Institut Ruđer Bošković
Cristina Sissa, Università di Parma

Document Type

Article

Publication Date

5-28-2024

Abstract

Neutral rhodol-based red emitters are shown to efficiently localize in mitochondria, as demonstrated by confocal microscopy and co-localization studies. A simple model is proposed to explain the localization mechanism of neutral molecules. The model takes into account the strong coupling between the molecular dipole moment and the electric field of the inner mitochondrial membrane.

Identifier

85194375618 (Scopus)

Publication Title

Organic and Biomolecular Chemistry

External Full Text Location

https://doi.org/10.1039/d4ob00252k

ISSN

14770520

PubMed ID

38804835

First Page

5886

Last Page

5890

Issue

29

Volume

22

Grant

101007804-Micro4Nano

Fund Ref

Horizon 2020

Recommended Citation

Ferraboschi, Ilaria; Ovcar, Juraj; Vygranenko, Kateryna V.; Yu, Shupei; Minervino, Alfonso; Wrzosek, Antoni; Szewczyk, Adam; Rozza, Riccardo; Magistrato, Alessandra; Belfield, Kevin D.; Gryko, Daniel T.; Grisanti, Luca; and Sissa, Cristina, "Neutral rhodol-based dyes expressing localization in mitochondria" (2024). Faculty Publications. 410.
https://digitalcommons.njit.edu/fac_pubs/410