A multimodal meta-analysis of regional structural and functional brain alterations in type 2 diabetes

Document Type

Article

Publication Date

7-1-2021

Abstract

Neuroimaging studies have identified brain structural and functional alterations of type 2 diabetes mellitus (T2DM) patients; however, there is no systematic information on the relations between abnormalities in these two domains. We conducted a multimodal meta-analysis of voxel-based morphometry and regional resting-state functional MRI studies in T2DM, including fifteen structural datasets (693 patients and 684 controls) and sixteen functional datasets (378 patients and 358 controls). We found, in patients with T2DM compared to controls, conjoint decreased regional gray matter volume (GMV) and altered intrinsic activity mainly in the default mode network including bilateral superior temporal gyrus/Rolandic operculum, left middle and inferior temporal gyrus, and left supramarginal gyrus; decreased GMV alone in the limbic system; and functional abnormalities alone in the cerebellum, insula, and visual cortex. This meta-analysis identified complicated patterns of conjoint and dissociated brain alterations in T2DM patients, which may help provide new insight into the neuropathology of T2DM.

Identifier

85104743222 (Scopus)

Publication Title

Frontiers in Neuroendocrinology

External Full Text Location

https://doi.org/10.1016/j.yfrne.2021.100915

e-ISSN

10956808

ISSN

00913022

PubMed ID

33862036

Volume

62

Grant

19PJ078

Fund Ref

Sichuan Province Science and Technology Support Program

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