Translational application of neuroimaging in major depressive disorder: a review of psychoradiological studies

Document Type

Article

Publication Date

8-1-2021

Abstract

Major depressive disorder (MDD) causes great decrements in health and quality of life with increments in healthcare costs, but the causes and pathogenesis of depression remain largely unknown, which greatly prevent its early detection and effective treatment. With the advancement of neuroimaging approaches, numerous functional and structural alterations in the brain have been detected in MDD and more recently attempts have been made to apply these findings to clinical practice. In this review, we provide an updated summary of the progress in translational application of psychoradiological findings in MDD with a specified focus on potential clinical usage. The foreseeable clinical applications for different MRI modalities were introduced according to their role in disorder classification, subtyping, and prediction. While evidence of cerebral structural and functional changes associated with MDD classification and subtyping was heterogeneous and/or sparse, the ACC and hippocampus have been consistently suggested to be important biomarkers in predicting treatment selection and treatment response. These findings underlined the potential utility of brain biomarkers for clinical practice.

Identifier

85099870174 (Scopus)

Publication Title

Frontiers of Medicine

External Full Text Location

https://doi.org/10.1007/s11684-020-0798-1

e-ISSN

20950225

ISSN

20950217

PubMed ID

33511554

First Page

528

Last Page

540

Issue

4

Volume

15

Grant

81171488

Fund Ref

National Natural Science Foundation of China

This document is currently not available here.

Share

COinS