Multi-organs-on-chips for testing small-molecule drugs: Challenges and perspectives

Document Type

Article

Publication Date

10-1-2021

Abstract

Organ-on-a-chip technology has been used in testing small-molecule drugs for screening potential therapeutics and regulatory protocols. The technology is expected to boost the development of novel therapies and accelerate the discovery of drug combinations in the coming years. This has led to the development of multi-organ-on-a-chip (MOC) for recapitulating various organs involved in the drug–body interactions. In this review, we discuss the current MOCs used in screening small-molecule drugs and then focus on the dynamic process of drug absorption, distribution, metabolism, and excretion. We also address appropriate materials used for MOCs at low cost and scale-up capacity suitable for high-performance analysis of drugs and commercial high-throughput screening platforms.

Identifier

85117517588 (Scopus)

Publication Title

Pharmaceutics

External Full Text Location

https://doi.org/10.3390/pharmaceutics13101657

e-ISSN

19994923

Issue

10

Volume

13

Grant

DC18818

Fund Ref

National Institutes of Health

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