Peptide-Based Inhibitors for SARS-CoV-2 and SARS-CoV

Document Type

Article

Publication Date

10-1-2021

Abstract

The COVID-19 (coronavirus disease) global pandemic, caused by the spread of the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) virus, currently has limited treatment options which include vaccines, anti-virals, and repurposed therapeutics. With their high specificity, tunability, and biocompatibility, small molecules like peptides are positioned to act as key players in combating SARS-CoV-2, and can be readily modified to match viral mutation rate. A recent expansion of the understanding of the viral structure and entry mechanisms has led to the proliferation of therapeutic viral entry inhibitors. In this comprehensive review, inhibitors of SARS and SARS-CoV-2 are investigated and discussed based on therapeutic design, inhibitory mechanistic approaches, and common targets. Peptide therapeutics are highlighted, which have demonstrated in vitro or in vivo efficacy, discuss advantages of peptide therapeutics, and common strategies in identifying targets for viral inhibition.

Identifier

85111869463 (Scopus)

Publication Title

Advanced Therapeutics

External Full Text Location

https://doi.org/10.1002/adtp.202100104

e-ISSN

23663987

Issue

10

Volume

4

Grant

IIP 1903617

Fund Ref

National Science Foundation

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