The translational values of TRIM family in pan-cancers: From functions and mechanisms to clinics
Document Type
Article
Publication Date
11-1-2021
Abstract
Cancer is the second leading cause of human death across the world. Tripartite motif (TRIM) family, with E3 ubiquitin ligase activities in majority of its members, is reported to be involved in multiple cellular processes and signaling pathways. TRIM proteins have critical effects in the regulation of biological behaviors of cancer cells. Here, we discussed the current understanding of the molecular mechanism of TRIM proteins regulation of cancer cells. We also comprehensively reviewed published studies on TRIM family members as oncogenes or tumor suppressors in the oncogenesis, development, and progression of a variety of types of human cancers. Finally, we highlighted that certain TRIM family members are potential molecular biomarkers for cancer diagnosis and prognosis, and potential therapeutic targets.
Identifier
85109048779 (Scopus)
Publication Title
Pharmacology and Therapeutics
External Full Text Location
https://doi.org/10.1016/j.pharmthera.2021.107881
e-ISSN
1879016X
ISSN
01637258
PubMed ID
33930453
Volume
227
Grant
18HASTIT048
Fund Ref
National Natural Science Foundation of China
Recommended Citation
Zhao, Guo; Liu, Chuan; Wen, Xin; Luan, Gan; Xie, Longxiang; and Guo, Xiangqian, "The translational values of TRIM family in pan-cancers: From functions and mechanisms to clinics" (2021). Faculty Publications. 3694.
https://digitalcommons.njit.edu/fac_pubs/3694
