Utilization of Raman spectroscopy in nanomaterial/bionanomaterial detection

Document Type

Syllabus

Publication Date

1-1-2022

Abstract

Raman Spectroscopy has been an essential technology in characterizing the natural and man-made nanostructures based on their vibrational modes. The technique is meritorious to study the complexity of cellular structures in detail without the necessity of vacuum. It works on the principle of inelastic scattering of light referred to as the Raman scattering that gives away the structural fingerprint of the studied material. The technique owns various advanced variants including the surface-enhanced Raman spectroscopy and surface-enhanced spatially offset Raman Spectroscopy. These techniques are utilized for detecting the nanomaterials dwelling inside human and other mammalian cells. This technology offers a great advantage of not being invasive and can detect the presence of nanomaterials in tissues of several millimeters in thickness. Additionally, as Raman spectroscopy is unaffected by water, it is a highly suitable technology in bio-environment. In the present chapter, the mechanism of detection by the Raman spectroscopy would be discussed in detail along with briefing up of data analysis techniques. Role of the technique in detection of nanoparticles to negate severe illnesses would be highlighted. Thus, the chapter would demonstrate the significance of Raman Spectroscopy in nanotechnology and detection of chronic illness due to uptake and prolonged residence of nanomaterials by mammalian cells.

Identifier

85137881146 (Scopus)

ISBN

[9780128235935, 9780128234266]

Publication Title

Handbook of Microbial Nanotechnology

External Full Text Location

https://doi.org/10.1016/B978-0-12-823426-6.00015-2

First Page

145

Last Page

156

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