Common and distinct neurofunctional representations of core and social disgust in the brain: Coordinate-based and network meta-analyses

Document Type

Article

Publication Date

4-1-2022

Abstract

Disgust represents a multifaceteddefensive-avoidanceresponse. On the behavioral level, the response includes withdrawal and a disgust-specific facial expression. While both serve the avoidance of pathogens, the latter additionally transmits social-communicative information. Given that common and distinct brain representation of the primary defensive-avoidance response (core disgust) and encoding of the social-communicative signal (social disgust) remain debated, we employed neuroimaging meta-analyses to (1) determine brain systems generally engaged in disgust processing, and (2) segregate common and distinct brain systems for core and social disgust. Disgust processing, in general, engaged a bilateral network encompassing the insula, amygdala, occipital and prefrontal regions. Core disgust evoked stronger reactivity in left-lateralized threat detection and defensive response network including amygdala, occipital and frontal regions, while social disgust engaged a right-lateralized superior temporal-frontal network involved in social cognition. Anterior insula, inferior frontal and fusiform regions were commonly engaged during core and social disgust, suggesting a shared neurofunctional basis. We demonstrate a common and distinct neural basis of primary disgust responses and encoding of associated social-communicative signals.

Identifier

85124230237 (Scopus)

Publication Title

Neuroscience and Biobehavioral Reviews

External Full Text Location

https://doi.org/10.1016/j.neubiorev.2022.104553

e-ISSN

18737528

ISSN

01497634

PubMed ID

35122784

Volume

135

Grant

61871420

Fund Ref

National Natural Science Foundation of China

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