A BODIPY-Based Far-Red-Absorbing Fluorescent Probe for Hypochlorous Acid Imaging

Document Type

Article

Publication Date

4-1-2022

Abstract

Hypochlorous acid (HClO) is produced by white blood cells to defend against injury and bacteria. However, as one of the reactive oxygen species, high intracellular HClO concentration could lead to chronic diseases that affect the cardiovascular and nervous systems. To monitor HClO concentrations in bio-samples, the fluorescent probe is preferred to have: a) Absorbability in the far-red window with reduced light toxicity and improved tissue penetration depth; b) Ratiometric features for accurate analysis. In this study, we reported a far-red ratiometric HClO fluorescence probe based on BODIPY chromophore and aldoxime sensing group. Not only the color change of the probe solution can be detected by the naked eye, but also the emission ratios (I645/I670) showed a significant increase upon the introduction of HClO. More importantly, the feasibility of HClO monitoring in biosamples was demonstrated in vitro using a confocal microscope.

Identifier

85122669005 (Scopus)

Publication Title

Chemphotochem

External Full Text Location

https://doi.org/10.1002/cptc.202100250

e-ISSN

23670932

Issue

4

Volume

6

Grant

1R21GM140438‐01

Fund Ref

National Institutes of Health

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