Selection of natural biomaterials for micro-tissue and organ-on-chip models

Document Type

Article

Publication Date

5-1-2022

Abstract

The desired organ in micro-tissue models of organ-on-a-chip (OoC) devices dictates the optimum biomaterials, divided into natural and synthetic biomaterials. They can resemble biological tissues' biological functions and architectures by constructing bioactivity of macromolecules, cells, nanoparticles, and other biological agents. The inclusion of such components in OoCs allows them having biological processes, such as basic biorecognition, enzymatic cleavage, and regulated drug release. In this report, we review natural-based biomaterials that are used in OoCs and their main characteristics. We address the preparation, modification, and characterization methods of natural-based biomaterials and summarize recent reports on their applications in the design and fabrication of micro-tissue models. This article will help bioengineers select the proper biomaterials based on developing new technologies to meet clinical expectations and improve patient outcomes fusing disease modeling.

Identifier

85123918836 (Scopus)

Publication Title

Journal of Biomedical Materials Research Part A

External Full Text Location

https://doi.org/10.1002/jbm.a.37353

e-ISSN

15524965

ISSN

15493296

PubMed ID

35102687

First Page

1147

Last Page

1165

Issue

5

Volume

110

Grant

R21DC018818

Fund Ref

National Institute on Deafness and Other Communication Disorders

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