Cells and material-based strategies for regenerative endodontics

Document Type

Article

Publication Date

8-1-2022

Abstract

The carious process leads to inflammation of pulp tissue. Current care options include root canal treatment or apexification. These procedures, however, result in the loss of tooth vitality, sensitivity, and healing. Pulp capping and dental pulp regeneration are continually evolving techniques to regenerate pulp tissue, avoiding necrosis and loss of vitality. Many studies have successfully employed stem/progenitor cell populations, revascularization approaches, scaffolds or material-based strategies for pulp regeneration. Here we outline advantages and disadvantages of different methods and techniques which are currently being used in the field of regenerative endodontics. We also summarize recent findings on efficacious peptide-based materials which target the dental niche.

Identifier

85120402183 (Scopus)

Publication Title

Bioactive Materials

External Full Text Location

https://doi.org/10.1016/j.bioactmat.2021.11.015

ISSN

2452199X

First Page

234

Last Page

249

Volume

14

Grant

IIP 1903617

Fund Ref

National Science Foundation

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