Polymer coating/encapsulation of nanoparticles using a supercritical anti-solvent process

Document Type

Article

Publication Date

1-1-2004

Abstract

Coating or encapsulation of nanoparticles is a major challenge due to the extremely small size, high surface energy, and high surface area of the nanoparticles. In this paper we describe a new method using supercritical CO2 as an anti-solvent (SAS) for nanoparticle coating/encapsulation. A model system, using silica nanoparticles as host particles and Eudragit polymer as the coating material, was chosen for this purpose. The SAS process causes a heterogeneous polymer nucleation with the nanoparticles acting as nuclei and a subsequent growth of polymer on the surface of the nanoparticles induced by mass transfer and phase transition. A polymer matrix structure of encapsulated nanoparticles is formed by agglomeration of the coated nanoparticles. Field emission scanning electron microscopy, transmission electron microscopy, electron energy loss spectroscopy and Fourier transform infrared spectroscopy were used to characterize the coated/encapsulated silica nanoparticles. © 2003 Elsevier B.V. All rights reserved.

Identifier

0344306362 (Scopus)

Publication Title

Journal of Supercritical Fluids

External Full Text Location

https://doi.org/10.1016/S0896-8446(03)00011-1

ISSN

08968446

First Page

85

Last Page

99

Issue

1

Volume

28

Grant

CTS-9985618

Fund Ref

National Science Foundation

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