Analysis of malignancy-associated DNA changes in interphase nuclei of buccal epithelium in persons with breast diseases

Document Type

Article

Publication Date

6-1-2004

Abstract

Aim: To study from the point of view of statistical and geometrical theory of pattern recognition, the peculiarities of the distribution of optical density of DNA in the interphase nuclei of mammary buccal epithelium upon pathology. Methods: Cytogenetic investigation of buccal smears and computer-based image analysis were used. Results: It is shown that in malignant neoplasms of the mammary glands compared with its values in benign, the optical density of DNA in the nuclei of buccal epithelium increase in a range from 0.15 to 0.30 conventional units. The sensitivity of that criterium varied from 80.5% to 96.8%, and specificity was 92.3%. Conclusion: The method proposed may be recommended as an additional one for improvement of the diagnosis of mammary pathologies.

Identifier

3242807491 (Scopus)

Publication Title

Experimental Oncology

ISSN

02043564

PubMed ID

15273669

First Page

158

Last Page

160

Issue

2

Volume

26

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