An analytical solution for percutaneous drug absorption: Application and removal of the vehicle

Document Type

Article

Publication Date

10-1-2005

Abstract

The methods of Laplace transform were used to solve a mathematical model developed for percutaneous drug absorption. This model includes application and removal of the vehicle from the skin. A system of two linear partial differential equations was solved for the application period. The concentration of the medicinal agent in the skin at the end of the application period was used as the initial condition to determine the distribution of the drug in the skin following instantaneous removal of the vehicle. The influences of the diffusion and partition coefficients, clearance factor and vehicle layer thickness on the amount of drug in the vehicle and the skin were discussed. © 2005 Elsevier Inc. All rights reserved.

Identifier

25844433716 (Scopus)

Publication Title

Mathematical Biosciences

External Full Text Location

https://doi.org/10.1016/j.mbs.2005.07.002

ISSN

00255564

PubMed ID

16135370

First Page

119

Last Page

139

Issue

2

Volume

197

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