Formation of polymer nano-particles in supercritical fluid jets

Document Type

Conference Proceeding

Publication Date

12-1-2005

Abstract

The supercritical antisolvent (SAS) process is an emerging technology for the production of micro- and nanometer-sized particles for a wide variety of bio-medical pharmaceutical applications [1]. In this paper, polyvinylpyrrolidone (PVP) nanoparticles are synthesized using dichloromethane (DCM) and acetone as organic solvents to prepare polymer solution and carbon dioxide in supercritical phase is used as an antisolvent. Several capillary nozzles from 20 μm to 127 μm are used to inject the solution at different Reynolds number. Particles from sub-micron size to nano size are obtained depending upon operating parameters.

Identifier

32044466690 (Scopus)

ISBN

[0976798506, 9780976798507]

Publication Title

2005 Nsti Nanotechnology Conference and Trade Show Nsti Nanotech 2005 Technical Proceedings

First Page

215

Last Page

217

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