Metabolic syndrome in aboriginal Canadians: Prevalence and genetic associations
Document Type
Article
Publication Date
1-1-2006
Abstract
Objectives: The prevalence rates of type 2 diabetes (T2DM) and coronary heart disease (CHD) in Ontario Oji-Cree are among the world's highest. Since metabolic syndrome (MetS) increases risk of T2DM and CHD, we characterized prevalence and putative genetic determinants of MetS in Oji-Cree. Methods and results: In 515 adult (≥18 years old) and 115 adolescent (<18 years old) Oji-Cree subjects, using the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria, we determined that 29.9% of Oji-Cree adults, and 43.4% of adults ≥35 years of age, had MetS. Furthermore, 33.9 and 8.7% of female Oji-Cree adults and adolescents, respectively, had MetS. Increased waist girth and depressed HDL cholesterol were the most prevalent individual MetS components, while increased blood pressure was least prevalent. AGT T174M, GNB3 825C>T, and APOC3 -455T>C genotypes were significantly associated with MetS (P = 0.018, 0.0056, and 0.029, respectively) for female adults, whereas FABP2 A54T genotype was associated with MetS (P = 0.040) for female adolescents. Conclusions: The high MetS prevalence in Oji-Cree adults, especially women, is consistent with their high risk of T2DM and CHD. Functional polymorphisms in three candidate genes for plasma lipoproteins and blood pressure were associated with MetS in adult Oji-Cree. Furthermore, several female adolescents met the adult MetS criteria, suggesting that the genesis of MetS begins in youth, especially among aboriginal females. © 2005 Elsevier Ireland Ltd. All rights reserved.
Identifier
28344451684 (Scopus)
Publication Title
Atherosclerosis
External Full Text Location
https://doi.org/10.1016/j.atherosclerosis.2005.03.024
ISSN
00219150
PubMed ID
15869758
First Page
121
Last Page
129
Issue
1
Volume
184
Fund Ref
Canadian Institutes of Health Research
Recommended Citation
Pollex, Rebecca L.; Hanley, Anthony J.G.; Zinman, Bernard; Harris, Stewart B.; Khan, Hafiz M.R.; and Hegele, Robert A., "Metabolic syndrome in aboriginal Canadians: Prevalence and genetic associations" (2006). Faculty Publications. 19269.
https://digitalcommons.njit.edu/fac_pubs/19269
