The effects of local platelet rich plasma delivery on diabetic fracture healing

Authors

Ankur Gandhi, Newark College of Engineering
Christopher Dumas, Rutgers New Jersey Medical School
J. Patrick O'Connor, Rutgers New Jersey Medical School
J. Russell Parsons, Rutgers New Jersey Medical School
Sheldon S. Lin, Rutgers New Jersey Medical School

Document Type

Article

Publication Date

1-1-2006

Abstract

Several studies have documented that diabetes impairs bone healing clinically and experimentally. The percutaneous delivery of platelet rich plasma (PRP) was used in the diabetic BB Wistar femur fracture model to investigate the use of PRP as a concentrated source of critical early growth factors on bone healing. PRP delivery at the fracture site normalized the early (cellular proliferation and chondrogenesis) parameters while improving the late (mechanical strength) parameters of diabetic fracture healing. These results suggest a role for PRP in mediating diabetic fracture healing and potentially other high risk fractures. © 2005 Elsevier Inc. All rights reserved.

Identifier

33644977736 (Scopus)

Publication Title

Bone

External Full Text Location

https://doi.org/10.1016/j.bone.2005.10.019

ISSN

87563282

PubMed ID

16368279

First Page

540

Last Page

546

Issue

4

Volume

38

Recommended Citation

Gandhi, Ankur; Dumas, Christopher; O'Connor, J. Patrick; Parsons, J. Russell; and Lin, Sheldon S., "The effects of local platelet rich plasma delivery on diabetic fracture healing" (2006). Faculty Publications. 19247.
https://digitalcommons.njit.edu/fac_pubs/19247