Modeling and Simulation Based Approaches for Investigating Allosteric Regulation in Enzymes

Document Type

Article

Publication Date

1-1-2006

Abstract

Summary: Understanding complex biological processes such as regulation of enzymes requires development and application of new mathematical and computational models, tools and/or protocols, including homology-based modeling (HM) and molecular dynamics (MD) simulations. We demonstrate how these in silico methods can be used to advance our understanding of complex processes using the allosteric regulation of soluble guanynyl cyclase (sGC) as an example. Future directions for the sGC research are also identified.

Identifier

84880380143 (Scopus)

ISBN

[9783540255420]

Publication Title

Lecture Notes in Computational Science and Engineering

External Full Text Location

https://doi.org/10.1007/3-540-31618-3_2

ISSN

14397358

First Page

21

Last Page

34

Volume

49

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