BioMEMS sensor systems for bacterial infection detection: Progress and potential

Document Type

Article

Publication Date

1-1-2006

Abstract

The spread of drug-resistant bacteria represents a growing worldwide health problem. The most efficient way to fight drug-resistant bacteria is to detect their colonies, identify their type, monitor their growth, and destroy them before they reach the human body. A gravimetric biomedical micro-electro- mechanical sensor (BioMEMS) system operating in the pico-gram range (10 -12 g/cm2) has been proposed for detecting growth of drug-resistant bacterial colonies. The sensor is based on a MEMS metal-coated thin piezoelectric membrane resonator. A combination of shear horizontal surface acoustic (SHSAW), Bleustein-Gulyaev, skimming and 'leaky' waves, generated in the resonator, are highly sensitive to mass, density, viscoelastic, and electrochemical changes at the resonator/bacteria interface. Measuring resonant frequency shifts of the composite resonator provides information about the mass and type of the bacterium colony growing on the resonator. © 2006 Adis Data Information BV. All rights reserved.

Identifier

33846140021 (Scopus)

Publication Title

Biodrugs

External Full Text Location

https://doi.org/10.2165/00063030-200620060-00005

ISSN

11738804

PubMed ID

17176122

First Page

351

Last Page

356

Issue

6

Volume

20

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