The thermal analysis of films in the 21st century: Relevance to cell culture, biochips and roll-to-roll circuits

Document Type

Article

Publication Date

3-15-2006

Abstract

Films may be considered as wide fibers, or as unique material geometry possessing two dimensional symmetry (X, Y Z). Potentially different uniformity issues along the machine (long) and transverse directions of the film, characterization of Z-axis performance - especially as films become "thin" and the characterization/identification of surface modification, introduce the need for careful sampling strategies if the resulting thermal analysis data is to be reflective of either process history or end-use performance or both. Two dimensional imaging by a combination of techniques - i.e., DSC-WAXS-FTIR-AFM exploit the convenience of the sample geometry, while aiding in the definition of structural complexity. Molecular spectroscopy techniques (DMA, TSC) provide a sensitive and instructive tool for examining novel surface or interface chemistry. Characterization under biorelevant conditions (37 °C, aqueous, standard saline, presence of adhesive and other proteins, presence of cells) is critical for the generation of meaningful data on films to be utilized biologically (cell culture, tissue engineering substrates, biochips). Of special interest are strategies for accelerated aging that allow prediction of biological or biorelevant performance. © 2006 Elsevier B.V. All rights reserved.

Identifier

33644954641 (Scopus)

Publication Title

Thermochimica Acta

External Full Text Location

https://doi.org/10.1016/j.tca.2006.01.024

ISSN

00406031

First Page

87

Last Page

91

Issue

1-2

Volume

442

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