Asymmetric reduction of aromatic ketones in pyridinium-based ionic liquids

Authors

Ying Xiao, New Jersey Institute of Technology
Sanjay V. Malhotra, New Jersey Institute of Technology

Document Type

Article

Publication Date

4-3-2006

Abstract

The asymmetric reduction of aromatic ketones has been studied in pyridinium-based room temperature ionic liquids, namely, 1-ethyl-pyridinium tetrafluoroborate, [EtPy]⁺[BF4]^- and 1-ethyl-pyridinium trifluoroacetate, [EtPy]⁺[CF3COO]^-. Ionic liquids were employed as solvents, while (R)-BINOL and (R)-BINOL-Br were used as chiral promoters. The effects of solvent, reaction time, temperature, catalyst loading and substituents were investigated. The reduction could be easily carried out in both ionic liquids with lower catalyst loading. 1-Ethyl-pyridinium tetrafluoroborate was recycled and reused efficiently. © 2006 Elsevier Ltd. All rights reserved.

Identifier

33646511307 (Scopus)

Publication Title

Tetrahedron Asymmetry

External Full Text Location

https://doi.org/10.1016/j.tetasy.2006.03.032

e-ISSN

1362511X

ISSN

09574166

First Page

1062

Last Page

1065

Issue

7

Volume

17

Recommended Citation

Xiao, Ying and Malhotra, Sanjay V., "Asymmetric reduction of aromatic ketones in pyridinium-based ionic liquids" (2006). Faculty Publications. 19002.
https://digitalcommons.njit.edu/fac_pubs/19002