Quantitative Models of Developmental Pattern Formation

Document Type

Article

Publication Date

9-1-2006

Abstract

Pattern formation in developing organisms can be regulated at a variety of levels, from gene sequence to anatomy. At this level of complexity, mechanistic models of development become essential for integrating data, guiding future experiments, and predicting the effects of genetic and physical perturbations. However, the formulation and analysis of quantitative models of development are limited by high levels of uncertainty in experimental measurements, a large number of both known and unknown system components, and the multiscale nature of development. At the same time, an expanding arsenal of experimental tools can constrain models and directly test their predictions, making the modeling efforts not only necessary, but feasible. Using a number of problems in fruit fly development, we discuss how models can be used to test the feasibility of proposed patterning mechanisms and characterize their systems-level properties. © 2006 Elsevier Inc. All rights reserved.

Identifier

33747871080 (Scopus)

Publication Title

Developmental Cell

External Full Text Location

https://doi.org/10.1016/j.devcel.2006.08.006

ISSN

15345807

PubMed ID

16950121

First Page

289

Last Page

300

Issue

3

Volume

11

Grant

P01 CA41086

Fund Ref

National Science Foundation

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