Synthesis and immobilization of micro-scale drug particles in presence of β-cyclodextrins

Authors

Xiangxin Meng, New Jersey Institute of Technology
Dachuan Yang, Ethicon, Inc.
Golshid Keyvan, Department of Chemical and Biochemical Engineering
Bozena Michniak-Kohn, Ernest Mario School of Pharmacy
Somenath Mitra, New Jersey Institute of Technology

Document Type

Article

Publication Date

4-1-2012

Abstract

The anti-solvent synthesis in presence of cyclodextrins (CDs) of the drug Griseofulvin (GF) is presented. This was followed by immobilization into cellulosic polymer films suitable for drug delivery. The results show that 72% of the GF precipitated in presence of CD, while the rest led to the formation of a water soluble GF/CD complex. The cyclodextrins were effective in inhibiting particle growth and stabilizing the drug suspensions. Among the CDs tested here, hydroxypropyl-β-cyclodextrin (HPBCD) was found to be most effective in reducing the particle size. The release profiles from the cyclodextrin stabilized GF particles showed improvement in release rate, which indicated effective drug/cyclodextrin interactions. © 2011 Elsevier B.V.

Identifier

84856080334 (Scopus)

Publication Title

Colloids and Surfaces B Biointerfaces

External Full Text Location

https://doi.org/10.1016/j.colsurfb.2011.11.043

e-ISSN

18734367

ISSN

09277765

PubMed ID

22186134

First Page

213

Last Page

222

Volume

92

Grant

0540855

Fund Ref

National Science Foundation

Recommended Citation

Meng, Xiangxin; Yang, Dachuan; Keyvan, Golshid; Michniak-Kohn, Bozena; and Mitra, Somenath, "Synthesis and immobilization of micro-scale drug particles in presence of β-cyclodextrins" (2012). Faculty Publications. 18310.
https://digitalcommons.njit.edu/fac_pubs/18310