Gold-Catalyzed Diyne-Ene Annulation for the Synthesis of Polysubstituted Benzenes through Formal [3+3] Approach with Amide as the Critical Co-Catalyst
Document Type
Article
Publication Date
9-23-2024
Abstract
The one-step synthesis of tetra-substituted benzenes was accomplished via gold-catalyzed diyne-ene annulation. Distinguished from prior modification methods, this novel strategy undergoes formal [3+3] cyclization, producing polysubstituted benzenes with exceptional efficiency. The critical factor enabling this transformation was the introduction of amides, which were reported for the first time in gold catalysis as covalent nucleophilic co-catalysts. This interesting protocol not only offers a new strategy to achieve functional benzenes with high efficiency, but also enlightens potential new reaction pathways within gold-catalyzed alkyne activation processes.
Identifier
85201615334 (Scopus)
Publication Title
Angewandte Chemie - International Edition
External Full Text Location
https://doi.org/10.1002/anie.202407360
e-ISSN
15213773
ISSN
14337851
PubMed ID
38973064
Issue
39
Volume
63
Grant
R01GM147135
Fund Ref
National Institutes of Health
Recommended Citation
Wei, Jingwen; Pham, Thong; Attah, Emmanuel Ifeanyi; Liu, Mengjia; Yaroshuk, Timothy; Chen, Hao; Wojtas, Lukasz; and Shi, Xiaodong, "Gold-Catalyzed Diyne-Ene Annulation for the Synthesis of Polysubstituted Benzenes through Formal [3+3] Approach with Amide as the Critical Co-Catalyst" (2024). Faculty Publications. 183.
https://digitalcommons.njit.edu/fac_pubs/183
