Modulation of network pacemaker neurons by oxygen at the anaerobic threshold

Document Type

Article

Publication Date

7-1-2012

Abstract

Previous in vitro and in vivo studies showed that the frequency of rhythmic pyloric network activity in the lobster is modulated directly by oxygen partial pressure (PO 2). We have extended these results by (1) increasing the period of exposure to low PO 2 and by (2) testing the sensitivity of the pyloric network to changes in PO 2 that are within the narrow range normally experienced by the lobster (1 to 6 kPa). We found that the pyloric network rhythm was indeed altered by changes in PO 2 within the range typically observed in vivo. Furthermore, a previous study showed that the lateral pyloric constrictor motor neuron (LP) contributes to the O 2 sensitivity of the pyloric network. Here, we expanded on this idea by testing the hypothesis that pyloric pacemaker neurons also contribute to pyloric O 2 sensitivity. A 2-h exposure to 1 kPa PO 2, which was twice the period used previously, decreased the frequency of an isolated group of pacemaker neurons, suggesting that changes in the rhythmogenic properties of these cells contribute to pyloric O 2 sensitivity during long-term near-anaerobic (anaerobic threshold, 0.7-1.2 kPa) conditions. © 2012 Springer-Verlag.

Identifier

84862663559 (Scopus)

Publication Title

Journal of Comparative Physiology A Neuroethology Sensory Neural and Behavioral Physiology

External Full Text Location

https://doi.org/10.1007/s00359-012-0725-2

e-ISSN

14321351

ISSN

03407594

PubMed ID

22526113

First Page

511

Last Page

523

Issue

7

Volume

198

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