Transillumination imaging for blood oxygen saturation estimation of skin lesions

Document Type

Article

Publication Date

9-3-2012

Abstract

Detecting the early stages of melanoma can be greatly assisted by an accurate estimate of subsurface blood volume and blood oxygen saturation, indicative of angiogenesis. Visualization of this blood volume present beneath a skin lesion can be achieved through the transillumination of the skin. As the absorption of major chromophores in the skin is wavelength dependent, multispectral imaging can provide the needed information to separate out relative amounts of each chromophore. However, a critical challenge to this strategy is relating the pixel intensities observed in a given image to the wavelength-dependent total absorption existing at each spatial location. Consequently, in this paper, we develop an extension to Beers law, estimated through a novel voxel-based, parallel processing Monte Carlo simulation of light propagation in skin which takes into account the specific geometry of our transillumination imaging apparatus. We then use this relation in a linear mixing model, solved using a multispectral image set, for chromophore separation and oxygen saturation estimation of an absorbing object located at a given depth within the medium. Validation is performed through the Monte Carlo simulation, as well as by imaging on a skin phantom. Results show that subsurface oxygen saturation can be reasonably estimated with good implications for the reconstruction of 3-D skin lesion volumes using transillumination toward early detection of malignancy. © 2012 IEEE.

Identifier

84865467429 (Scopus)

Publication Title

IEEE Transactions on Biomedical Engineering

External Full Text Location

https://doi.org/10.1109/TBME.2012.2209647

e-ISSN

15582531

ISSN

00189294

PubMed ID

22835531

First Page

2660

Last Page

2667

Issue

9

Volume

59

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