Miscibility characterization of indomethacin and Eudragit® E PO by rheological and thermal analysis

Document Type

Conference Proceeding

Publication Date

9-10-2012

Abstract

The miscibility between drug indomethacin and excipient Eudragit* E PO were extensively characterized by rheological and thermal analysis. The evolution of glass transition temperature and activation energy with indomethacin concentration indicates the existence of overall positive deviation which represents anti-plasticization effect. The rheological analysis is in agreement with the thermal analysis, and both methods indicate that the miscibility between them is very good for indomethacin concentrations up to 60-70%.

Identifier

84865765095 (Scopus)

ISBN

[9781622760831]

Publication Title

Annual Technical Conference ANTEC Conference Proceedings

First Page

71

Last Page

75

Volume

1

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