Crystallization of acetaminophen/poly(ethylene oxide) mixtures

Document Type

Conference Proceeding

Publication Date

9-11-2012

Abstract

A model drug acetaminophen was mixed with PEO, and the morphology, nucleation numbers, and crystallization kinetics of PEO were altered accordingly. The spherulitic growth rate and isothermal DSC endotherm were analyzed by Hoffman-Lauritzen theory and Avrami theory, respectively. It was found that the fold surface free energy increased significantly with increasing drug content, indicating the chain folding of PEO became much more difficult in the presence of the small molecule drug.

Identifier

84865828817 (Scopus)

ISBN

[9781622760831]

Publication Title

Annual Technical Conference ANTEC Conference Proceedings

First Page

2074

Last Page

2079

Volume

3

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