Increasing drug release rate through foamed structures

Document Type

Conference Proceeding

Publication Date

9-11-2012

Abstract

The influence of foam morphology on the release rate of Indomethacin (INM) from a solid solution prepared by hot melt extrusion was investigated. Closed cell foams were produced through a batch process, employing CO 2 as physical blowing agent. In all cases foamed disks showed faster INM's release than un-foamed disks. The time required for completing INM's release was reduced up to 75% mainly due to extensive and random breakage of the sample during dissolution test.

Identifier

84865821995 (Scopus)

ISBN

[9781622760831]

Publication Title

Annual Technical Conference ANTEC Conference Proceedings

First Page

1784

Last Page

1790

Volume

3

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