Effects of screw configuration on indomethacin dissolution behavior in Eudragit e PO

Document Type

Article

Publication Date

12-1-2012

Abstract

This experimental study examines the evolution of the extent of dissolution of the active pharmaceutical ingredient (API) indomethacin (INM) into the polymer excipient Eudragit E PO (E PO) on four screw configurations processed in an APV 15 mm corotating twin screw extruder. The screws were pulled out and quenched by water, which allowed for quick access to the processed stream carcass. Polarized light microscopy (PLM), scanning electron microscopy (SEM), and Fourier transform infrared spectroscopy (FT-IR), were employed to investigate the evolution of INM's dissolution into the molten excipient along the extrusion direction. The FT-IR results show that kneading blocks accelerate the complete dissolution process. The unique capability of fully filled kneading blocks in mixing and melting associated with the dissolution of API into polymeric excipient matrix was discussed. © 2011 Wiley Periodicals, Inc. Adv Polym Techn 31: 331-342, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/adv.20256 Copyright © 2011 Wiley Periodicals, Inc.

Identifier

84867739319 (Scopus)

Publication Title

Advances in Polymer Technology

External Full Text Location

https://doi.org/10.1002/adv.20256

e-ISSN

10982329

ISSN

07306679

First Page

331

Last Page

342

Issue

4

Volume

31

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